Understanding and modulating the MR1 metabolite antigen presentation pathway

The MHC class I-related protein, MR1, presents small metabolite antigens to an unusual subset of innate-like T cells. Herein, we highlight recent progress in our understanding MR1's unique antigen presenting pathway, with features both I and II presentation, as highlighted during the EMBO Workshop: CD1-MR1, Beyond MHC-restricted lymphocytes, Oxford, 2019. There is increasing evidence for a role MR1 restricted cells several immune contexts, from cancer autoimmunity infections, therapeutic harnessing this important biological axis through generation agonist antagonist ligands requires thorough molecular mechanisms MR1-dependent presentation.